> For the complete documentation index, see [llms.txt](https://www.parapathology.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://www.parapathology.com/medical-school-lectures/general-pathology/the-mechanisms-of-cell-death-apoptosis-and-autophagy.md).

# The Mechanisms of Cell Death, Apoptosis, and Autophagy

Required Prior Knowledge:

Aim of the Lecture:

Goals of the lecture:

Lecture Outlines:

* Analogy for necrosis and apoptosis
* Differences between necrosis and apoptosis
* * Morphologic features of necrosis and steps of necrosis development
  * Morphologic features of apoptosis and steps of apoptosis development
* Necrosis
* * Nuclear changes in necrosis
  * * Pyknosis
    * Karyolysis
    * Karyorrhexis
  * Necrosis, morphology, its effect to regional tissue and its removal
* Apoptosis
* * Factors controlling apoptosis
  * Physiologic Causes of Apoptosis
  * Pathologic Causes of Apoptosis
  * Mechanisms of apoptosis
  * * The Mitochondrial (Intrinsic) Pathway of Apoptosis
    * The Death Receptor (Extrinsic) Pathway of Apoptosis
    * Caspases
    * Clearance of Apoptotic Cells
  * Examples of Apoptosis
* Necroptosis
* Pyroptosis
* Autophagy

References:

1. Robbins Basic Pathology, 9th edition
2. Robbins and Cotran Pathologic Basis of Disease, 9th edition
3. Programmed cell death:<https://www.coursera.org/course/pcd>

{% embed url="<https://www.youtube.com/watch?v=gGgay06WmoQ>" %}

## Hücre ölümünün mekanizmaları, Apoptoz ve Otofaji

Ders adı:Hücre ölümünün mekanizmaları, Apoptoz ve Otofaji

Ders öncesi bilinmesi beklenenler:

Dersin Amacı:

Dersin hedefleri:

Başlıklar:

* Nekroz ve apoptoz için anolojiler
* Nekroz ve apoptoz arasındaki farklılıklar
* * Nekrozun morfolojik özellikleri ve nekroz gelişiminin basamakları
  * Apoptozun morfolojik özellikleri ve apoptoz gelişiminin basamakları
* Nekroz
* * Nekrozdaki nükleer değişiklikler
  * * Piknozis
    * Karyolizis
    * Karyoreksiz
  * Nekroz, morfolojisi, çevre dokulara etkisi ve ortadan kaldırılması
* Apoptoz
* * Apoptozu kontrol eden faktörler
  * Apoptozun fizyolojik nedenleri
  * Apoptozun patolojik nedenleri
  * Apoptoz mekanizmaları
  * * Apoptozun mitokondriyal (intrinsik) yolağı
    * Apoptozun ölüm reseptörü (ekstrinsik) yolağı
    * Kaspazlar
    * Apoptotik hücrelerin temizlenmesi
  * Apoptoz örnekleri
* Nekroptoz
* Piroptoz
* Otofaji

Kaynaklar:

1. Robbins Basic Pathology, 9th edition
2. Robbins and Cotran Pathologic Basis of Disease, 9th edition
3. Programmed cell death:<https://www.coursera.org/course/pcd>

Son güncelleme:01.05.2015