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The Mechanisms of Cell Death, Apoptosis, and Autophagy

Required Prior Knowledge:

Aim of the Lecture:

Goals of the lecture:

Lecture Outlines:

  • Analogy for necrosis and apoptosis

  • Differences between necrosis and apoptosis

    • Morphologic features of necrosis and steps of necrosis development

    • Morphologic features of apoptosis and steps of apoptosis development

  • Necrosis

    • Nuclear changes in necrosis

      • Pyknosis

      • Karyolysis

      • Karyorrhexis

    • Necrosis, morphology, its effect to regional tissue and its removal

  • Apoptosis

    • Factors controlling apoptosis

    • Physiologic Causes of Apoptosis

    • Pathologic Causes of Apoptosis

    • Mechanisms of apoptosis

      • The Mitochondrial (Intrinsic) Pathway of Apoptosis

      • The Death Receptor (Extrinsic) Pathway of Apoptosis

      • Caspases

      • Clearance of Apoptotic Cells

    • Examples of Apoptosis

  • Necroptosis

  • Pyroptosis

  • Autophagy

References:

  1. Robbins Basic Pathology, 9th edition

  2. Robbins and Cotran Pathologic Basis of Disease, 9th edition

Hücre ölümünün mekanizmaları, Apoptoz ve Otofaji

Ders adı:Hücre ölümünün mekanizmaları, Apoptoz ve Otofaji

Ders öncesi bilinmesi beklenenler:

Dersin Amacı:

Dersin hedefleri:

Başlıklar:

  • Nekroz ve apoptoz için anolojiler

  • Nekroz ve apoptoz arasındaki farklılıklar

    • Nekrozun morfolojik özellikleri ve nekroz gelişiminin basamakları

    • Apoptozun morfolojik özellikleri ve apoptoz gelişiminin basamakları

  • Nekroz

    • Nekrozdaki nükleer değişiklikler

      • Piknozis

      • Karyolizis

      • Karyoreksiz

    • Nekroz, morfolojisi, çevre dokulara etkisi ve ortadan kaldırılması

  • Apoptoz

    • Apoptozu kontrol eden faktörler

    • Apoptozun fizyolojik nedenleri

    • Apoptozun patolojik nedenleri

    • Apoptoz mekanizmaları

      • Apoptozun mitokondriyal (intrinsik) yolağı

      • Apoptozun ölüm reseptörü (ekstrinsik) yolağı

      • Kaspazlar

      • Apoptotik hücrelerin temizlenmesi

    • Apoptoz örnekleri

  • Nekroptoz

  • Piroptoz

  • Otofaji

Kaynaklar:

  1. Robbins Basic Pathology, 9th edition

  2. Robbins and Cotran Pathologic Basis of Disease, 9th edition

Son güncelleme:01.05.2015

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